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Indications with high cost-effectiveness values were more likely to be reimbursed (ρ = −0.68, P = 0.001).
The results show that enhanced TNMCA was able to infer meaningful indications with high performance compared to the ABC model and previous TNMCA model.
We found that indications with high cost-effectiveness values (lower ICERs) were more likely to be reimbursed, which suggests that each country considers cost-effectiveness in addition to clinical efficacy when deciding the reimbursement of a certain drug.
The results show that enhanced TNMCA was able to infer meaningful indications with high performance (AUC = 0.801, 0.829) compared to the ABC model (AUC = 0.7050) and previous TNMCA model (AUC = 0.5679, 0.7469).
Similar(56)
As described above, interactive compounds often share similar functions [ 16, 23], thereby having similar indications with higher probability.
Other indication with high compliance rate were blood pressure ≥140/90 mmHg, abnormal lie/presentation and uterus too big for gestational age in the prenatal complication group and labour for >12 hours/obstructed in the natal complication group.
For example, the proportion of oncology patients eligible for standard 1-line or 2-line treatment is usually well documented for oncology indications with a high prevalence, e.g. colon carcinoma, lung carcinoma, and breast carcinoma.
The two indications with the highest proportion of dexamethasone prescribing were non-specific and neurological symptoms (29.9% and 31.6% of dexamethasone events respectively).
AMT were not given targets, and therefore might have chosen other priorities for interventions than the indications analysed here, despite these being the indications with the highest volume of patients receiving AM.
Open reduction internal fixation (ORIF) indications were, fractures with high risk of neurovascular injury and engagement of the distal aspect of the proximal fragment in brachial muscles and unsatisfactory closed reductions.
Application of this strategy is based on chemical and pharmacological similarities of compounds with clinical evidence of suicidal intent, target or indication classes associated with high incidence of SIB, in vitro neuropharmacological activity profile, in vivo ADME properties, patient population of the underlying indication and regulatory precedents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com