But they are less likely to single out individual physicians for not being aggressive, particularly when the indications are less certain.
They are likely less frequently used by beginners because their medical indications are less common and their technique is more difficult without specific training.
In other patient groups the indications are less clear but in general, profound deficiency of T-cell mediated immunity predisposes to complications of EBV infection.
Tetracyclines are generally used in the treatment of urinary tract and intestinal infections, and are used in the treatment of chlamydial infections, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
However, regulatory pathways for obtaining a prevention indication are less well charted, and such trials tend to involve 3- to 7-year studies of 1000 - 5000 individuals, depending on baseline status.
In fact, when the indication is less clear-cut, discontinuation may be less likely to occur.
In particular, confounding by indication is less likely, as all subjects were exposed to the variable of interest [ 14].
Antibiotic prescribing for a clinical indication was less often required at examinations of amoxicillin children (55%) then placebo children (68%) (adjusted risk ratio = 0.67 [0.36, 1.22] p = 0.190).
While for primary congenital glaucoma goniotomy represents the procedure of choice, this indication is less certain for other forms of childhood glaucoma [ 62].
Clinicians frequently face a dilemma when deciding on statin initiation as primary prevention, particularly in those without diabetes and those with apparently mildly elevated cardiovascular disease risk factors when the indication is less clear and evidence less strong.
