Exact(1)
Because drug indications can be viewed as drug functions, it is appropriate to use known drug indications to predict drugs with unknown indications.
Similar(59)
Finally, we tried to look for a specific function of the proposed methyltransferase, and binding of the geneticin bound to the eubacterial 16S rRNA A-site (PDB code: 1MWL) in the active site of the PF0847 gave us the indication to predict the protein responsible for aminoglycoside antibiotic resistance.
Its management needs some indications about scale to predict occurrence of populations and communities.
To test the generalization of this method, it was conducted on DSte to predict indications of drug compounds in it.
"In other words, everything that we have seen, looked at, there is no indication of being able to predict this stunning series of crimes," Mr. Kelly said.
By integrating chemical interactions and chemical similarities, the indications of a given drug compound d q were predicted as follows: the method based on chemical interactions (cf. (2 )) was first applied to predict the indications; if the outcomes of (2 ) are trivial as indicated by (4 ), the method based on chemical similarities (cf. (5 )) was then used to make further prediction.
the method based on chemical interactions (cf. (2)) was first applied to predict the indications; if the outcomes of (2) are trivial as indicated by (4), the method based on chemical similarities (cf. (5)) was then used to make further prediction.
As described above, our major goal was to utilize the information that is stored in biological networks and thus focus our attention on network topological features to predict drug indications.
In the study, we built an effective classifier to predict drug indications based on chemical interactions extracted from STITCH database and chemical structure similarity.
Likewise, because compounds with similar structures often share common functions [ 20], chemical similarities were applied to predict drug indications if chemical interactions give no meaningful result.
The pharmacological spectrum of each drug is not necessarily well covered, yet it would be the best way to predict new indications.
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