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In total, nine fracture zones have been identified with and without permeability indications (Table 1).
Treatment-specific sections were drafted for 11 different categories of therapy procedures and indications (Table 1).
Almost all patients underwent a CT prior to the LP [89.9% (86.1 94.6 ], independently of LP indications (Table 1).
The search for CNS infections were most frequent among the elderly patients, representing almost 80% of LP indications (Table 1).
Thus, 864 unique molecules are used in 884 different major therapeutic area indications (Table 4), and the 328 unique targets are distributed amongst 351 major uses (Table 5).
For example, CD28, CD40, and TNFRSF4 (OX40) antagonists are in early stage clinical trials for treatment of various immune disorders, whereas CD28, CD40, and TNFRSF4 (OX40) agonists are in early stage clinical trials for various cancer indications (Table 10).
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For 20 (4.5 %) episodes, revision of HR or KR was identified as indication (Table 2).
These promising results led to a series of phase 2 evaluations in the indication (Table 4).
Univariable analysis demonstrated that decannulation was related to year, admission unit, reason for admission, and tracheostomy indication (Table 3).
Because of aforementioned reasons, bioactive glass has also been studied for treatment of this clinical indication (Table 4) [ 36– 36].
The treatment is expensive, and the regulatory authorities have recommended a more restrictive approach than the approved indication (Table 1).
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