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Indications, study designs and the usage of additional treatments within the identified studies were quite heterogeneous.
Indications, study designs, outcome parameters and the usage of additional treatments within the few identified studies enrolling EYT were quite heterogeneous.
Although indications, study designs, outcome parameters, and the usage of additional treatments within the identified studies enrolling EYT were quite heterogeneous, these studies describe improvements of the symptoms (with relevant effect sizes in most cases; Figure 1), which can be ascribed to effects of the multimodal treatment approaches of AM which enrol EYT.
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For the indications studied, tonsillectomy remains the treatment of choice and should not be delayed or even denied to those children.
For example, the statement in the ICHS6, "for those biopharmaceuticals intended for chronic use indications, studies of 6 months duration have generally been appropriate…"; is this still relevant?
This appears higher than the rates previously reported in other indications studied with patupilone.
Table 2 shows the results for the different infertility indications studied.
17 This suggests that tacrolimus eye drops are equivalent to cyclosporine for the indications studied here.
The values quoted refer to the total time for preparation followed by administration of the medication, averaged over medications, wards and indications studied.
The figures quoted refer to the total time for preparation and administration of each medication per day, averaged over wards and indications studied.
Indication, study design, patient age, length of follow-up, and type of procedure had no statistically significant influence on the magnitude of the ceiling effect (p-values all > 0.05).
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