Treatments proposed for cartilage lesions are described with their rationale and indications, ranging from conservative measures to surgical approaches, reparative or regenerative.
One of the study's two senior co-authors, neuroimmunologist Larry Steinman, MD, has published several articles in the past few years on the substance's anti-inflammatory properties and possible therapeutic benefits in indications ranging from multiple sclerosis (his specialty) to heart attack.
Corresponding daily doses recommended by clinical guidelines also vary across indications, ranging from 750 to 4000 mg/day (Amoxicillin and clavulanate, 2016).
Awareness of when to use CPU for true indications ranged from a high of 2.14 (often to always) for cardiac tamponade and a low of 0.25 (never to sometimes) for elevated intracranial pressure.
A subsequent international survey that specifically investigated the use of nebulized antibiotics in ICUs highlighted very heterogeneous indications ranging from prophylactic or empirical therapy to documented lung infections in immunocompetent and immunocompromised patients, for VAT and VAP [70].
However, in the previous studies, uncertain indications ranged from 7%to36.8%8%.
As described in Section 2.2, the query drug was assigned a series of candidate indications, ranging from the most likely one to the least one.
Fetal indications ranged from 9.4%too 27.2%; the leading indication was "fetal compromise"; we did not collect additional information from the patient file, such as fetal heart rate, to validate the fetal compromise indication.
While pain control and epilepsy are still the major focus of interest in terms of sodium channel drug development, it remains possible that indications ranging from autism to immune disorders may be modulated by compounds targeted at sodium channel activity.
> There are now more than 180 therapeutic proteins and peptides approved by the US Food and Drug Administration FDAA) for a wide variety of indications, ranging from alleviation of neuropathic pain to rheumatoid arthritis and replacement enzymes for lysosomal storage diseases.
