Both concentrations of gefitinib used gave similar results, with no indication of dose dependency of gefitinib in the concentrations used, although their effects on growth differed.
There was no indication of dose dependency in PK in the 400 μg to 2800 μg delivered dose range in the GMAD study.
As an indication of dose modification, the percentage of values where absolute value of relative difference was >10% was also given.
For some metals, there is some evidence that loading is a better indication of dose than is concentration; in studies of children's exposure to lead, the surface loading of lead on carpet was more strongly correlated with blood lead levels than was the concentration of lead in the dust [ 15, 16].
18 19 In vivo models testing anti-inflammatory combinations containing a low dose steroid have demonstrated a synergistic interaction between the steroid and the enhancing agent that produces an effect equivalent to that of a high dose steroid alone, without indications of high dose steroid side effects.
We demonstrated consistent, statistically significant effects of THM exposure on LBW and BW with an indication of dose-response relation.
For meningioma, there was a reduction in risk of 22% for male subscribers, with some variations by years of follow-up but again no indication of dose-response relation.
There was no indication of dose-response relation either by years since first subscription for a mobile phone or by anatomical location of the tumour that is, in regions of the brain closest to where the handset is usually held to the head.
We used total U-As as a measure of in utero exposure to arsenic because urinary arsenic levels have been suggested to provide reliable indications of internal dose (Marchiset-Ferlay et al. 2012), and arsenic is known to readily cross the placenta, leading to fetal serum concentrations similar to maternal levels (Concha et al. 1998).
A higher dose of 100 μCi was required for a single systemic administration to achieve ∼80% inhibition, and indications of a dose-dependent response were seen.
