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Recently, Van Loon et al 36 considered five arguments that limit the feasibility of RCTs in the evaluation of novel radiotherapy technologies, namely, rare indications, narrow inclusion criteria, end points that require data for late toxic effects or second malignant disease, limited funding and a strong belief in effectiveness of the novel technique.
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IMSPI retained a normal segment's motor function, with less trauma, lower cost, and so forth, but the indications are narrower than for SSPI, and its reduction was less effective than with SSPI.
However, other studies found some indication of narrowing of socioeconomic differences in smoking in the UK [16], [17].
Clinical studies exclude many comorbidities or factors that may suggest nonresponse in order to reduce variability, resulting in indication statements narrowed to the exact population studied in phase III.
Latest indications suggest a narrow but shrinking majority in favour of the latest agreement, with 55% of voters who have made up their minds intending to back it.
Narrow indications, which are without a sound rational basis, will in this era of constant oversight by third party payers affect physicians' ability to manage patients with psoriasis.
As surgeons are worried about the revision rate of UKA they will tend to use narrow indications and just operate on patients they would consider to be ideal.
Therefore a vicious circle may develop in which surgeons, who are anxious about revision of UKA, have narrow indications and do small numbers, and then have a high revision rate.
But who cared?" The Black Dahlia will probably do better than De Palma's recent releases, but it's a sad indication of how narrow the concerns of movie-making have become when a director who's still taking risks this late in his career doesn't have the space to do his own thing.
We have narrower indications for newer, ingrowth tantalum components.
The spectra also exhibited an absorption maximum, which is an indication of a narrow particle size distribution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com