All together, docetaxel has five different indications, three in specific clinical situations for advanced breast cancer and two for advanced or metastatic non-small-cell lung cancer.
Prof. Alberto Angeli from the Ethical Committee of the University of san Luigi Gonzaga assessed the study and confirmed that ethical approval was not needed since the study deals with a non-invasive diagnostic tool used according to its standard indications in a specific subset of patients, for which previous indications of the literature are available.
55 However, as previously mentioned, while PDK1 is integral to the PI3K/AKT pathway, there is a growing indication that in specific cancer settings, PDK1 may have important functions that are AKT independent.
We obtain an indication of changes in specific areas by gathering data on explanatory factors, like coping, problem solving, and future orientation, but we cannot tell which element of the training is responsible for these changes.
Medicines are approved for marketing based upon a determination that their benefits outweigh foreseeable risks in specific indications, specific populations, and at specific dosages and regimens.
On the other hand, fewer CXRs may result from utilization of alternative techniques in specific indications.
Although replaced by spiral volumetric scan modes in most routine CT studies, sequential acquisition is still available in modern scanner because of its superiority in specific indications [15] and has been proposed in lung imaging to reduce dose exposure [16].
This is however a pilot study, and its results encourage further evaluation of the role of CZT technology in specific indications of bone scan as well as scintigraphy using other tracers.
Already early in the innovation process economic evaluations can support decisions on development in specific indications or patient groups by anticipating future reimbursement and implementation decisions.
