Similar indications occur in several physiological disorders and in normal situations of stress or fear, but they may be considered neurotic when they occur in the absence of any organic defect or pathology and in situations that most people handle with ease.
Notably, homozygosity of the R155H mutation is lethal, with these animals dying by 21 days of age with indications of abnormalities in several systems including muscle, brain and spinal cord (the complex phenotype of these animals will be fully characterized in a separate publication).
6 8 Since the first publication making this indication in 2009, several studies have investigated copeptin.
Unrewarded visits have been reported as an indication of hunger in several studies (De Paula Vieira et al., 2008).
Rates of evolution in ND1 show indications of relative acceleration in several terminal branches within Henophidia.
Bevacizumab, a humanised monoclonal antibody that binds specifically to VEGF-A alone, has shown efficacy in several indications in the metastatic setting.
It is currently approved in several indications: As second-line monotherapy for locally advanced or metastatic breast cancer (Taxotere®, 2005 ).
Tyrosine kinase inhibitors (TKIs), designed to inhibit VEGF receptor signalling (Fig. 2), have demonstrated single-agent activity in several indications.
Antibodies conjugated with cytotoxic agents, such as drugs or radionuclides, have shown promising results in several indications (Govindan and Goldenberg, 2010; Sharkey and Goldenberg, 2011).
Dabigatran etexilate (DE), rivaroxaban, and apixaban are nonvitamin K antagonist oral anticoagulants (NOACs) that have been compared in clinical trials with existing anticoagulants (warfarin and enoxaparin) in several indications for the prevention and treatment of thrombotic events.
