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There are no physical indications found for this therapeutic class.
There were 2501 drug repositioning candidates (excluding 13 known indications) found by both of the clustering approaches (Additional file 5).
Finally, some of the indications found here have the potential for conversion to acute situations with prolonged wait.
A recent review of safety data from ADA clinical studies across indications found a stable rate of serious infections throughout ADA exposure, which may be attributed to differences in populations and methodology [ 26].
A meta‐analysis of 16 placebo controlled trials of aspirin for cardiac and other indications found that aspirin increased the absolute risk of cerebral haemorrhage by 12 events per 30 000 person‐years of follow up.
This is in keeping with a meta-analysis of randomised controlled trials of anti-TNF in RA. 27 Conversely, another randomised controlled trial meta-analysis of anti-TNF across all indications found a twofold increased risk of skin cancer.
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Finally, the critiquing module is run for each indication found in the prescription.
Thus, the indication found in our study that immigrant children are more likely to have received suboptimal care which failed to prevent an asthma exacerbation is novel.
In our own series of patients receiving FVIIa following trauma – perhaps the largest single center experience in the world – TBI is the second leading indication, found in about 150 out of 350 patients [ 2].
This will, if recent trends are any indication, find expression at the polls and drive Congress even further away from free trade.
No apparent indications were found.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com