Sentence examples for indications for existing from inspiring English sources

Drug repositioning or repurposing is a principle of discovering novel therapeutic indications for existing approved drugs, which provides an alternative and cost-efficient strategy of discovering disease therapeutics [36].

These predicted drug targets can be divided into two types: I) unexploited novel drug targets that can be used alone or with other drugs in combination chemotherapy treatment [3]; II) existing drug targets that provide new uses and indications for existing drugs [4].

The bill opens a path for the FDA to approve new uses, or indications, for existing drugs without demanding thorough clinical tests conducted along customary lines.

A comparative analysis of gene signatures derived from a large collection of compound treatment experiments can identify those compounds with similar biological properties, pinpoint treatments with toxic side-effects, and discover novel indications for existing compounds [11].

Among the 5,008 disease-drug links, connections with negative scores suggest new indications for existing drugs, such as the use of some antimalaria drugs for Crohn's disease, and a variety of existing drugs for Huntington's disease; while the positive scoring connections can aid in drug side effect identification, such as tamoxifen's undesired carcinogenic property.

This would apply equally to new agents and to new adult height indications for existing agents.

Substantial differences in reported odds ratios among other studies form an extra indication for existing heterogeneity.

However, while in the management plan reference is made to the proposed MPAs, no indications of restrictions for existing activities in these selected areas are proposed.

The authors emphasized that there are more indications for planets existing around dying stars, calling the pairing "a general process that we expect to take place in other circumstances," Bear and Soker said.

In summary, our study demonstrated that gene expression signature-based in silico drug discovery is potentially valuable for the identification of new indications of existing compounds, which is critical for translational research and clinical applications.

One such strategy is drug repositioning (or repurposing) in which a new indication for an existing drug is identified.