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All of this evidence would thus not support the conclusions of most of the studies included [23, 28, 29, 31] (Table 1), in which clear indications for a given maturational stage in the identification of the growth phase were reported.
It is unclear if this shall remain the default or the exception either for new CIT candidates or for new combinations and indications for a given CIT.
Thus, determining which medications are specific enough to be used for case definitions is difficult in primary care as indications for a given medication change over time and may vary among practitioners.
New benefits and/or an extension of the indications for a given benefit may only be prescribed after the Federal Joint Committee has recognized their therapeutic value and included them into its directive (SGB V, Sect. 138).
Similar(56)
Although several treatment options have been proposed, clinical results are controversial and often the indication for a given therapy remains a matter of clinician choice.
The DADDDK is specified per animal species and is a standardized dose in mg/kg per day for the main indication of a given active ingredient and a specified route of administration and pharmaceutical form.
This kind of bias occurs when no agreed-upon indications exist for a given treatment or procedure, which is the case for RRT despite the recent publication of recommendations for the prevention and management of AKI in the intensive care unit (ICU) [ 7].
When multiple decisions matching these criteria existed for a particular drug-indication combination for a given agency, the first such decision was chosen for inclusion in the analysis to enable comparison of decisions based on the existing body of data without changing recommendations over time based on other external factors (pricing negotiations between the HTA body and the manufacturer).
Optimal dose-regimen selection attempts to select a drug input profile that offers the best benefit/risk ratio for a given indication in a given population.
Therefore, safety and efficacy may be addressed by designing HBOCs with modifications that limit hypertension, minimize heme destabilization and take into account endogenous Hb removal mechanisms to optimize exposure times for a given indication.
Drug safety evaluation is the key part of drug discovery and development process to identify those that have an appropriately balanced safety-efficacy profile for a given indication [57].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com