In Canada, the primary EU indications as established by the Canadian Emergency Ultrasound Society (CEUS) are (1) cardiac activity evaluation in the setting of cardiac arrest, (2) rule-out pericardial effusion, (3) rule-out intraperitoneal free fluid in trauma, (4) rule-out abdominal aortic aneurysm, and (5) rule-in intrauterine pregnancy.
The availability of a vast amount of experimental data covering various diseases has stimulated computational efforts to identify novel potential indications for established drugs.
Joel Dudley (NuMedii) presented a strategy for drug repositioning, in which publicly available gene expression data are used to predict new and often unexpected indications for established drugs.
In cases where the target of a drug is unknown or unclear, knowing the associations of nontarget mutations that correlate with treatment outcomes can inform the search for the actual target and/or suggest novel indications for established therapies.
We suggest a similar approach of assessing significance of overlap between genes linked to human diseases and networks controlling animal model perturbations can be useful in understanding the relevance of animal models and the exploration of new indications for established therapies.
This was done relatively often in case of an 'other' indication with established valve disease (37.5%), 'peripheral oedema' with established LVD (28.6%) or valve disease (30.4%), a cardiac murmur with established valve disease (28.2%), and dyspnoea with established LVD (25.6%).
In this study, we sought to establish indications for OR/IF and CR by examining five cases of pathologic fractures after postoperative radiation therapy [6, 7].
These parameters are increasingly used in the ICU in addition to clinical evaluation to establish indications for blood transfusion.
This, however, requires further studies that will identify the optimal forms of treatment for SDB, which will establish indications for its use and identify patients that are most likely to benefit clinically.
The purpose of this study was a comparison of conventional radiographic views with different CT reconstructions with 2 D and 3 D imaging to establish indications for additional CT diagnostics depending on the fractured parts.
