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BCL Conf is compared to other methods in three measures which are critical in computational drug discovery process: (a) the ability to generate conformation close to experimentally observed structure, (b) diversity of conformations indication coverage of sample space of molecules, (c) performance in terms of speed.
Each graph presents the % of target (Drug Bank, CHEMBL) or indications (CMC) coverage as a function of the subset size for five of the 25 fingerprints evaluated in this work (see Additional file 1: Tables S1 S3 for details for all fingerprints).
There are indications that coverage rates have continued to decline.
Figure 17 Optimized network in a large exhibition hall, using the rules for large isolated rooms (see Section 1), with indication of coverage ranges and adding order (the coverage range of access point 6 is not shown in the figure).
One approximate indication of coverage completeness is the number of Gm genes that are matched by Cf transcripts, so that Gm genes without Cf homologs suggest "missing" Cf genes.
For most of the themes considered no differences were apparent; where there was an indication that coverage of themes differed (taken at conventional levels of significance, p < 0.05), it was articles in the 'middle market tabloids' that tended to differ from those in the 'serious' and 'tabloid' newspapers.
CT has been covered by CMS since November 1985 for a variety of indications, but the coverage decision did not specify whether breast cancer staging was among them.
We then selected their 19 indications to ensure coverage of a variety of both solid and hematologic malignancies, and mechanisms of action.
Reasonable indications for enterococcal coverage include septic shock, prolonged treatment with cephalosporins, immunosuppression, presence of prosthetic heart valves and recurrent IAI with associated severe sepsis.[ 44– 47] When enterococcal infections are suspected, coverage should be included in the empirical regimen.
"Relative to other market changes, there is no indication that required coverage for women's health benefits was a primary driver of premium increases," Caroline Pearson of the consulting firm Avalere Health told The Associated Press. .
The representation of conserved gene classes also provides an approximate indication of transcriptome coverage.
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