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Although more studies and clinical validation of let-7b and miR-21 indications are necessary, these early works suggest ways in which miRNA biomarkers could complement current clinically used protein markers to improve prognostic assessment and to guide treatment decisions.
These indications are necessary for a definite diagnosis of XLA: the patient must be male and have less than 2%CD19++ B cells with mutations in the BTK gene, absent BTK mRNA on a northern blot analysis of neutrophils or monocytes, absent BTK proteins in monocytes or platelets, as well as maternal cousins, uncles, or nephews who have mutations [ 8].
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A compelling medical indication is necessary for interventions that might have irreversible consequences for the person's sex or negative consequences on their sexuality or reproductive capability.
Clinical indications joined to prescriptions are necessary for a good analysis.
Further studies are necessary before standard indications for bilateral hybrid hearing implantations can be established.
In order to attain precise indications, it is necessary to wait for data from the Phase III AIO KRK 0207 trial, which compares maintenance therapy with bevacizumab alone versus bevacizumab plus fluoropyrimidines versus observation.
Thus, the details in the medical records are necessary for accurate indication classification.
Large-scale studies are necessary in order to better define precise indications and treatment modalities in aging and elderly individuals.
More studies are necessary to confirm these results and define the indications for HFPV.
Clinical trials overseen by the FDA are necessary to determine the efficacy of FMT in alternative indications.
Clearly, further studies are necessary to evaluate the efficacy of the extract in different indications.
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CEO of Professional Science Editing for Scientists @ prosciediting.com