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The numbers and types of transplants have increased as unrelated and mismatched related individuals are now used as alternative donors, as different sources of hematopoietic stem cells are employed, and as new disease indications are considered for transplantation (Kernan et al., 1993; Kurtzberg et al., 1996; Walters et al., 1996).
Metformin is primarily used for type 2 diabetes, but is increasingly being used in polycystic ovary syndrome, non-alcoholic fatty liver disease (NAFLD) and premature puberty, three other diseases that feature insulin resistance; these indications are considered experimental.
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In another study [ 20], alerts for excluded indications were considered to be false-positives but the authors did not indicate the extent of the problem.
Indications were considered as critical, important, and all indications.
Three main indications were considered: fistula, malignant invasion and extrinsic compression.
3 TOP beyond 24 weeks' gestation for these indications is considered to be extremely rare.
In contrast, subsequent submissions for previously-reviewed drugs that were based on new indications were considered as separate, individual recommendations.
The association with asthma vanished when only non-pulmonary indications were considered, and the OR for wheeze was substantially reduced.
In efforts to save development time and minimize the risk of failure during drug develo pment, repositioning of currently available drugs to new therapeutic indications is considered an alternative route [1].
Of all persons taking part in the Rotterdam Study, those with MRI contra-indications are considered not eligible for the Rotterdam Scan Study.
Of all persons taking part in the Rotterdam Study, those who are demented or with MRI contra-indications are considered not eligible for the Rotterdam Scan Study.
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