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The defined daily dosage (DDD), which is the average dosage of a drug taken by adults for the most frequent indication, was computed according to the anatomic therapeutic chemical (ATC) classification system from WHO [ 9].
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Given a query drug d q, the score that d q can treat indication D j was computed by (11) R integrated d q ⟹ D j = R i d q ⇒ D j + R s d q ⇒ D j 2, h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h j = 1, 2, …, 56, where s is ECFP_4 and the parameters k in R i (d q ⇒ D j ) and R s (d q ⇒ D j ) were 5 and 2, respectively.
In addition, the across-replicate correlation between genetic group estimates was computed as an indication of sampling correlation of genetic group solutions.
The RMS of σ θ was computed for each bin, giving an indication of phase sensitivity for cones across the volume.
Pearson correlation across the samples of interest was computed (using R) between RAD21 and c-Myc log-intensities as an indication of expression correlation.
RAS was computed daily.
Since different drug compounds have different numbers of known indications, we set the parameter t in (7) to the smallest integer that is no less than the average number of known indications in the dataset, which can be computed by (8) Average = ∑ j = 1 N N j N ; that is, t = ⌈Average⌉.
If there are indications of within replicate field variation a second ANOVA using a nearest-neighbor adjustment is computed based on the nearest 8-plot mean.
Monthly averages were computed.
SES is computed daily.
And perhaps another indication was required.
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