The lack of data on clear indications, together with the suggestion of possible harm in this study, calls for studies on the risk benefit of platelet transfusion in the critically ill.
Thus, further examination into clinician decision-making about CD indications together with women's influence and involvement in these decisions may help explain the observed differences.
On the basis of these indications, ORCHESTRA, together with the project ANTARES [3], has promoted the web site VEGA (http://www.vega-qsar.eu), which provides a highly detailed explanation on the analysis of model results for a given substance.
Prospective studies with comprehensive sequential reporting of changes to technique and indication are recommended, together with standardisation of terminology Cite this as: BMJ 2013 346:f3012013 346
In an additional 72 other patients, clinical presentation showed indications of FTLD together with symptomatology of other neurodegenerative brain diseases such as Alzheimer or Parkinson disease.
Most likely, this is caused by a new indication of UC, which together with CD is the main indication of anti-TNF in gastrointestinal diseases.
Furthermore, there was a significant increase in autophagy and micronuclei, which is an indication of genomic instability, together with the activation of nuclear factor kappa-B (NF-κB) and mitochondrial inducible nitric oxide synthase (iNOS) signaling pathways in ρ+ SAE cells.
If a bisphosphonate has been prescribed, the type will be recorded including alendronate, risedronate, tiludronate, pamidronate, zoledronate or etidronate together with indication for use (osteoporosis, Paget's disease, glucorticoid-induced osteoporosis, metastatic disease, hypercalcemia).
Observations and discussion notes collected by the different investigators were all pooled together, with indication of the origin of each item (original comments by physicians or interpretation by investigators).
The species-specific occurrence of the alcohols and the macrolides, only found in the samples of H. viridiflavus and H. cinnamomeoventris, are a good indication that those volatiles together with the terpenes may be used to create species-specific cocktails of chemicals.
