Finally, the scenario including vaccine potential impact against head and neck cancers (for which the vaccine has currently no indication) resulted in increasing the fiscal BCR from 1.7 to 2. The latter influence of the results can be explained from the reduction of male mortality and the relatively higher lifetime earnings of males.
The exclusions to minimise the chance of confounding by indication resulted in a study population at relatively low risk of cardiovascular disease.
All medications were classified into nine types for eleven indications, resulting in five drug related initiatives.
One product (imatinib) has been authorised for four indications, and two other products (sunitinib and dasatinib) have been authorised for two indications, resulting in 36 approved orphan indications.
Among children in this study, the addition of "severe anaemia" and "prostration" to current indications resulted in a significant improvement in the detection of invasive bacterial disease in both fatal and non-fatal cases.
In a pediatric ICU, Price et al found that 37% of CXRs could be avoided by establishing specific indications, thereby resulting in significant cost savings [ 2].
Exome sequencing of a single individual for a clinical indication may result in the identification of incidental deleterious variants unrelated to the indication for testing (secondary findings).
An advantage of using a limited range of drugs is that GPs become more familiar with drug dosages, contra-indications, interactions, etc., resulting in a lower incidence of side effects and dangerous interactions [ 5, 6].
The main results of our prospective case series are: a change in the indication spectrum resulted in a trend toward an increased survival rate compared with the retrospective comparator study [ 4]; and a significant reduction in the incidence of adverse events, especially ischaemic complications.
