False negative results lead to the wrong conclusion that the drug is ineffective for the indication, resulting in a loss of opportunity.
In the beginning, MRI was only performed on clinical indication resulting in MRI in half of the patients, but MRI was performed in all patients during the last year of inclusion and in the whole validation period.
Among children in this study, the addition of "severe anaemia" and "prostration" to current indications resulted in a significant improvement in the detection of invasive bacterial disease in both fatal and non-fatal cases.
All medications were classified into nine types for eleven indications, resulting in five drug related initiatives.
One product (imatinib) has been authorised for four indications, and two other products (sunitinib and dasatinib) have been authorised for two indications, resulting in 36 approved orphan indications.
The main results of our prospective case series are: a change in the indication spectrum resulted in a trend toward an increased survival rate compared with the retrospective comparator study [ 4]; and a significant reduction in the incidence of adverse events, especially ischaemic complications.
Improvements in surgical techniques, implant design, and adherence to indications have resulted in favorable outcomes after unicompartmental knee arthroplasty (UKA), particularly in an older population.
Expanding clinical indications have resulted in increasing numbers of patients being treated with a cardiac implantable electronic device (CIED).
However, continuous improvement in the quality of imaging studies and frequent use of ultrasonography for all kinds of indications have resulted in higher incidence of the findings of lesions in this part of the pancreas, for example, asymptomatic cystic or endocrine tumors [ 9].
