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No indication of toxicity was found.
There was no indication of toxicity revealed with MTT, LDH leakage, direct contact assay and clonogenic assay.
This is probably because the toxicity threshold was surpassed, as a further indication of toxicity under this condition; less mobility of animals in this group was observed compared to other test groups.
After each injection the mice had very slow movements and major decreases in cage activity for several hours – an indication of toxicity.
However, no staining with thioflavin S, FSB or AT100 was observed, suggesting that tau filaments were not present, nor was there any indication of toxicity, as shown by propidium iodide staining.
Body weight was used as an indication of toxicity.
Similar(47)
For toxicity, e.g. indications of toxicity potential considered when availability or adequacy of data is too poor to support a definitive or a screening assessment.
Contrary to this, three reviews by independent scientists approach the role of herbicide residues in GM crops or present indications of toxicity.
Another recent review [61] concludes that parts of published evidence in assessments of health risks of GMO foods are general indications of toxicity.
However, in situations where data availability or adequacy is too poor to support a definitive or a screening assessment, we propose that other indications of toxicity potential should be taken into account (Table 6).
Compared to virus injected alone or in Poloxamer 407, virus injected in SELP 815K had fewer and less severe indications of toxicity related to treatment as assessed by blood analysis, body weight, and histopathology of distant organs and the injection sites.
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CEO of Professional Science Editing for Scientists @ prosciediting.com