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To bypass this conflict, an ongoing trial (DeLOSII) uses the tumour response after short induction chemotherapy as assumed indication of susceptibility for the planned therapeutic protocol.
These data provide a proof of concept that major depressive disorder is a polygenic disorder, and that the number of risk genotypes may be an indication of susceptibility to the disorder and the severity.
In addition, a proof of concept is provided demonstrating that the number of risk genotypes may be an indication of susceptibility of major depressive disorder and the severity of the disorder.
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This gave an indication of expected susceptibility classes: − high, − moderate, − low.
However, to date, there has been no indication of why susceptibility might change with age.
However, the profiles of the two mitochondrial extracts were similar, giving no indication of enhanced susceptibility to aggregation of proteins in Mdj1-depleted mitochondria.
It has also been suggested that corneal biomechanical properties may reflect globe biomechanics and thus give an indication of the susceptibility of developing glaucomatous damage [ 6, 7].
The effect of the extract was higher against S. aureus than P. aeruginosa which is an indication of greater susceptibility of the former implicated as the major causal organism of boils [ 11].
This supports the notion that Major Depressive Disorder is polygenic, and that the number of risk genotypes may be an indication of the susceptibility to Major Depressive Disorder as well as the severity of the disorder.
Parental history of asthma is an indication of genetic susceptibility, so the absence of risk among those with parental history may also indicate that asthma caused by pollutants in fresh traffic exhaust is less likely to be inherited, or at least is not mediated through the same genetic pathways that account for asthma in the parents of these children.
For comparison, the position of the main indications of BC susceptibility according to previously published studies of non- BRCA1/2 linkage is shown in Figure 1c.
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