The network graph gives a first indication of signal-like patterns and conflict present in the alignments.
Therefore gene expression changes at E14.5 may provide an indication of signaling pathways that cause cysts rather than being a consequence of cyst formation.
There is clear indication of signaling disturbance evidenced by the altered expression of specific pathways; the major impact is manifested in pathways that affect DNA repair and chromatin organization in particular.
The multi-tracer study included more than one PET tracer in the same pig, but the [15O]water scans were performed first or at least five half-lives after administration of prior radiotracer (11C tracers, T ½ = 20 min); neither images nor blood data showed indications of signal contamination.
Post-translational modification is possibly an indication of altered signal transduction.
The average background score provides an indication of the signal strength associated with the lowest-intensity probes on each array.
Measuring the shifts in tuning only provides an indication of which signal is being represented the translation component or the resultant optic flow.
Although back in 1998, PknJ was predicted to be encoded in M. tuberculosis genome, work on this kinase has not progressed since there was no indication of associated signaling components [1].
Upregulation of the receptor Ptc is a direct indication of Hh signaling activation, since it is a Hh target gene.
In transformed cells, Akt1 appears to stimulate translocation of GLUT1 to the plasma membrane [ 107, 108]; however, there is currently no indication of what signaling molecules regulate the translocation of GLUT1 to the baso-lateral surface of mammary epithelial cells and to the Golgi at secretory activation.
In line with this, decreased phosphorylation of SMAD3, an indication of decreased signalling activity, has been reported during OA progression of murine models of OA [ 44, 45], and SMAD3 knockout mice have shown to develop OA-like features in their joints [ 46].
