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These are then pooled in a meta-analysis to give an overall indication of efficacy.
Others are pilot studies that should give an indication of efficacy to encourage the initiation of a fully powered trial.
These findings strongly suggest a potential value in employing such composite endpoints in future prospective small studies designed to establish an early indication of efficacy.
Therefore, surrogate endpoints that can be measured sooner and more frequently during the course of a clinical trial, are being used to provide an earlier indication of efficacy [ 9].
Surrogate markers for relapse are therefore required to obtain a preliminary indication of efficacy and sterilising activity of the drug, even though a phase III trial with estimation of relapse rates is eventually necessary.
We have confirmed that ultrasonography of MCPJ is an early, reliable indicator of therapeutic response in RA and it thus has the potential to reduce patient numbers required as well as the duration of clinical trials designed to give a preliminary indication of efficacy.
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The data also provided enough indications of efficacy — by sending "healthies" to sleep — to allow Merck to accelerate its process, and skip a formal proof-of-concept stage.
Results emerging from clinical trials with oncolytic viruses demonstrate the safety and feasibility of a virotherapeutic approach and provide early indications of efficacy.
Although these approaches have demonstrated tantalising indications of efficacy in a small group of individuals, they have not reached the threshold of therapeutic efficacy or safety.
Despite the indications of efficacy, studies (particularly of farmers and applicators) show that PPE is frequently not used (e.g., Perry et al. 2002).
Furthermore, where evidence to date is not yet of the highest quality, indications of efficacy are nonetheless worth noting as suggestive of potential for success.
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