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Patients could be provided with a low-cost try-out device capable of reliable titration, providing an indication of effectiveness and of patient acceptance of an OAm, although the effect of device shape and size on therapeutic outcome is not yet known.
16 The review's tentative conclusion reports "some indication" of effectiveness with speech and language therapy.
A first indication of effectiveness came indirectly from the seminal meta-analysis by Nunes & Levin 26.
However, it is important to note that this trial will only provide a preliminary indication of effectiveness and that its primary purpose is to assess feasibility and acceptability.
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Particularly, strengthening the designs of these studies could yield useful indications of effectiveness.
Another element of great interest, and arguably the more challenging element of this call for research collaboration, is to seek indications of effectiveness of instruction.
No randomised trials have been reported, but indications of effectiveness have been seen in time trends of mortality, cohort studies and case-control studies [ 38].
We aim to evaluate key trial parameters, such as recruitment and retention of participants, randomisation, levels of missing data and preliminary indications of effectiveness, to inform calculation of a sample size for powering a full trial.
Firstly, there is no active treatment control group so that any indications of effectiveness need to be interpreted with caution as we will not know whether possible benefits are a function of this specific treatment or structured treatment in general.
We also presented Cohen effect sizes to provide an indication of clinical effectiveness for easier interpretation.
This means that cumulative measures of the impact of the epidemic, which include infections prior to when the full effect is exerted, provide a less substantial indication of the effectiveness of this intervention [50].
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