There is indication therefore of both consumption of fashion, or an interest to do so, but also indication of financial constraint.
The presence of highly conserved phylogenetic footprints, in fact, is an indication of selective constraints acting on specific sequences [ 40].
A utility of the FLAGS ranking is that it provides, albeit indirectly, a gene-level indication of the selective constraint upon a gene, while most existing metrics such as phastCons [ 57] or PhyloP [ 58] provide a position-specific value.
As MCSs were derived from the most conserved subset of sequences from a 3-species sequence alignment, they served as a surrogate for sequence conservation, which can be an indication of functional importance/evolutionary constraint.
On the other hand, GNAS, a prototype house-keeping signal transduction molecule expressed in all cells, evolved much slower than most other proteins, with near perfect conservation between the human protein and that of other mammals, an indication of extreme functional constraint.
This may be taken as an indication of how income constraints can pressure rural people to keep on selling firewood and charcoal to meet their short-term needs without considering the long-term burdens on the natural resource base.
In summary, this element is a distinct and conserved, derived feature in vertebrate pol γ-α; for other metazoan groups, there is no clear indication of its evolutionary constraints.
In their similarities, we see indications of common constraints imposed by the phylogeny and the biomechanics of organisms.
indications of what constraints may/must/should be imposed on CML documents valid against this convention.
This variation is commonly interpreted as an indication of differences in selective constraints.
