Currently, every indication needs to be approved using the "gold standard", a randomized controlled trial, because such trials are considered less biased than observational studies.
In addition, a standard manufacturing and indication needs to be applied before the commercial frankincense oil can be used as an alternative or complementary therapy for treating bladder cancer.
The benefits of PPI therapy for appropriate indications need to be considered, along with the likelihood of the proposed risks.
That doesn't mean this mythical drug is without potential, only that its manufacture, dosage and medical indications need to be standardized to protect patients before it gains approval for widespread use.
Therefore, separate submodels for off-label indications need to be developed.
Some therapeutic classes are named by their activities and thus their indications needed to be determined, e.g. diuretics are represented as anti-hypertensive in VCM, and we considered contraceptives as indicated for preventing the risk of pregnancy.
"Hearing stories like these leads to public concern, especially when a drug is being used outside the approved indication, we need to be extra careful".
As allocation decisions may be based on some of these factors, confounding by indication will need to be addressed in the planned follow on study.
In addition, there are specific challenges for neurodegenerative disease indications that need to be addressed.
Carbon ion facilities, however, because of the 12-fold heavier mass of carbon ions compared to protons, are currently more costly than proton facilities, so that appropriate indications will need to be defined.
