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The second indication, known as destination therapy, applies to patients with refractory heart failure symptoms who have contraindications for transplant and require MCS.
We tested for all indications in aggregate, as well as for RCC, an indication known to respond to sunitinib in human beings (Motzer et al., 2006a, 2006b, 2009).
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Lee established a database PharmDB, an integrated tripartite database, coupled with Shared Neighborhood Scoring (SNS) algorithm, to find new indication of known drugs [ 8].
PharmDB, an integrated tripartite database, coupled with Shared Neighborhood Scoring (SNS) algorithm, would provide much more enriched information than general integrated databases and give us clues for finding new indication of known drugs.
The CPI signature of the small molecules, whose therapeutic area is unknown, can be compared with the CPI signatures of the existing drugs whose indications are known, providing a potential methodology for pharmaceutical innovation.
The main exclusion criteria were dementia, (psychiatric) disease interfering with cognitive testing or follow-up, WMH or SVD mimics and MRI contra-indications or known claustrophobia [20].
These indications are known in the literature as off-label use and are based on data published as case reports or observational studies, almost always demonstrating a beneficial effect [ 4].
Injudicious use of oxygen at high partial pressures (hyperoxia) for unproven indications, its known toxic potential, and the acknowledged roles of reactive oxygen species in tissue injury led to skepticism regarding its use.
But Mr. Boehner gave no indication he knew which way to turn.
Both Bland and Miles attended Prairie View A&M University, but not at the same time, and there is no indication they knew each other.
If the people eating brunch at the diner are any indication, New Yorkers know all about tomorrow's postponed election, know the candidates and the issues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com