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We address a highly controversially discussed issue - whether or not HES might be safe in specified subgroups of patients if correct indication is considered?
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The indication was considered unknown if the reason was not specifically documented.
The indication was considered 'definite' average-risk screening if screening was recorded and none of the CRC conditions or risk factors noted above were recorded.
Patients who received an excluded systemic psoriasis therapy for a psoriasis indication were considered nonresponders for the segment in which they first received the excluded medication and in all subsequent segments.
Cataract surgery for a specific indication was considered appropriate if the panel's median score was between 7 and 9 without disagreement, inappropriate if the value was between 1 and 3 without disagreement, or uncertain if the median rating was between 4 and 6 or if the members of the panel disagreed.
The indication was considered 'high-risk' screening if the test was performed for screening and the patient had a first-degree relative diagnosed with CRC before age 50, two or more second-degree relatives diagnosed at any age, or other familial syndromes.
3 TOP beyond 24 weeks' gestation for these indications is considered to be extremely rare.
In efforts to save development time and minimize the risk of failure during drug develo pment, repositioning of currently available drugs to new therapeutic indications is considered an alternative route [1].
In another study [ 20], alerts for excluded indications were considered to be false-positives but the authors did not indicate the extent of the problem.
Indications were considered as critical, important, and all indications.
Metformin is primarily used for type 2 diabetes, but is increasingly being used in polycystic ovary syndrome, non-alcoholic fatty liver disease (NAFLD) and premature puberty, three other diseases that feature insulin resistance; these indications are considered experimental.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com