However, CT is only performed in patients with clinical indications and in combination with local guidelines.
Overall, 64.1% of patients were treated for off-label indications, sometimes in combination with treatment for GFL.
In regions where the disease is known to occur, clinical symptoms and post-mortem lesions are important indications, especially in combination with the history of the disease and the region in which it occurs.
In these indications, capecitabine in combination with other cytotoxic agents, including docetaxel, oxaliplatin and irinotecan, has demonstrated high activity and an acceptable safety profile (Kerr et al, 2002; O'Shaughnessy et al, 2002; Sastre et al, 2002).
At the end of 2010, the FDA recommended removing bevacizumab's breast cancer indication due to lack of survival benefit; the European Medicines Agency has maintained its indication but only in combination with paclitaxel.
In general on starting insulin, any use of thiazolidinediones was markedly reduced where used in a significant proportion of the population, reflecting their limited indications in this combination, while in general, metformin was continued.
The indication to use taxanes in combination with trastuzumab or similar agents means that a substantial minority of women will be exposed to this increased toxicity.
This reflects differences in the indications mentioned in the product monographs; while infliximab is indicated for use in combination with methotrexate, 24 the monograph of etanercept mentioned that it "can be initiated in combination with methotrexate…or used alone".
28, 29 There are also indications that vitamin C in combination with vitamin E is superior than being used alone.
In DrugBank, the therapeutic indication descriptions (for example, "Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer") of drugs are listed, which needs further manual curation for specific diseases.
