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Each of the four options has its advantages and limitations and a differential indication has to be made in every single case of congenitally missing teeth.
For registration of a biological the efficacy on the specific indication has to be shown.
Traditionally, the assessment of toxicity and activity of drugs used in a new indication has to be performed in patients with measurable disease.
17 Despite the positive effect of surgery, the indication has to be assessed very carefully, and postoperative immobilization should be kept as brief as possible because a long immobilization leads to rapid deterioration of motor ability.
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The clinicians stated that some requests for CS without a medical indication have to be accepted.
When sample size was <20 patients adherence to policy and documenting indication had to be perfect to achieve the target.
Additionally all guidelines containing recommendation on clinical trials for specific indication have to be carefully scrutinized and updated in respect to the requirements for conducting clinical trials in the paediatric population taking into account the different age groups [ 9].
Moreover, the recent press release from Draximage clearly stated that formulation development of Infecton® targeting orthopaedic indications has, to date, not been successful and Draximage will allocate the resources devoted to this product to other projects (http://www.draxishealth.com/pdf/Draxis_Q3_PR_US_GAAP.pdf).
Certain indications have to date been well demonstrated.
Indications have to be carefully discussed in advance with the physician, remembering that some signs of aging will be attenuated but will not disappear.
Moxifloxacin is commonly used in this role and the use of this antibacterial fluoroquinolone outside its indication has contributed to a search for alternatives to conventional TQT studies [ 4].
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CEO of Professional Science Editing for Scientists @ prosciediting.com