It is important to recognize that biological studies give important indications for the development of treatments, but their results do not always directly translate into clinical findings, as previously shown by the same clinical outcome reported using two biologically completely different procedures [ 35].
Table 5 provides a rough indication of the development and running times for the algorithms developed, together with the time required for manual checking and processing of the results (times are estimated to cover the complete dataset where necessary).
Resulting tussock shape provides a clear indication for the long-term development of the pioneer zone.
Based on the results obtained from the Phase I and Phase II trials, the treatment of postmenopausal VVA was selected as the target indication for the Phase III development of ospemifene.
Furthermore, the application of the signature across a large set of human tumor samples revealed new indications of potential interest for the development of p53 HDM2 inhibitors, such as renal cell carcinoma and hepatocellular carcinoma, that had been previously missed due to their under-representation in the set of CCLE cell lines tested.
We believe that the results reported in this study provide a rationale for testing CD70-directed drug delivery in new indications and provide novel reagents for the development of screening tests.
The experimental outcomes provided sufficient indication to favour the development of a low cost detection system for rapid quantification of phthalates in beverages for industrial use.
However, the indications that the development appears to have already been offered for sale could raise basic questions about the use of statutory compulsory-purchase powers.
How many tumor indications should be investigated in the first wave for the development program to be cost-effective amid the uncertainties?
The inclusion of patient preferences in therapeutic decisions implies stronger patient focus and can be simultaneously valuable for the development of drug therapy in the indication of NSCLC.
