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In conclusion, this trial could have relevant implications for the clinical practice, showing that the simple combination of paracetamol 1,000 mg + caffeine 130 mg seems to be as efficient and safe as sumatriptan 50 mg by mouth, and this could be an important indication for patients suffering from migraine who cannot assume triptans.
The decision making as well as surgical indication for patients with the metastatic lesion is always difficult issue.
The indication for patients' inclusion in the study was RECIST PD, not amenable to surgical resection with R0 intent or accompanied by an unacceptable function loss or deficit.
Combining breast cancer and NSCLC with stage 2 and 3 cancer studies does not seem appropriate in light of the FDA cleared indication for patients with MBC.
Of the 9 guidelines addressing anticoagulation, three specified their indication for patients with an EF < 20 25% (D, Italy) or NYHA 3 and 4 (Russia).
Traditionally 4 ng/mL was often regarded as the cut-off to consider biopsy [ 6], but controversy exists about the biopsy indication for patients with PSA between 4 and 10 ng/mL [ 7– 9].
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The analysis of the Think-Aloud Protocols and the Free-Report Protocols implied a high degree of knowledge concerning two central aspects of the guidelines, the special treatment indications for patients with CHD and patients with diabetes.
One of these biases is confounding by indication, because aspirin is indicated for patients as secondary prevention for cardiovascular disease.
Alternatively, we may therefore need to focus on (nonlinear) variability indices as biomarkers and mouse-to-men translatable indications for patient stratification, disease progression or treatment response.
The distribution of cryoprecipitate use was evaluated by indication and for patients with documented bleeding.
Another limitation of this study is the small number of cases in the series; this is attributed to the indications for patient selection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com