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In addition, we found no indication for effect modification when stratifying by prematurity and infants with heart and lung conditions.
Severe or frequent hypoglycemia is an absolute indication for the modification of treatment regimens, including setting higher glycemic goals.
The results did not provide any indication for a modification of breast cancer risk related to oestrogens by SULT1A1 genotype (data not shown) and corroborate recent evidence indicating that sulfonation of oestrogens catalyzed by SULT1A1 is less relevant in normal breast tissue in physiological conditions [ 11, 12].
There was indication for an effect modification by smoking for upper aerodigestive tract and liver cancer in men and for colorectal cancer in women (P<0.1).
However, since there is no indication for a similar modification in ciliates and as the Tetrahymena Nup98A domain contains far fewer serines and threonines as potential modification sites than its vertebrate counterpart, we also had to consider other possibilities.
Are there any other indications for direct modification of this molecule by ER stress?
Although operationalization of comorbidities varied, no indications for effect modification were observed [ 50, 57].
Although statistically underpowered, they performed a stratified analysis within two levels of baseline literacy and found no indications for effect modification [ 75].
Indications for the modification to the initial antibiotic regimen were: intolerance of the oral regimen due to vomiting (one); development of severe oesophagitis (two) and persistent fever at 72 h without serious clinical deterioration (six).
24 In secondary analyses, we stratified cases and their matched controls according to the indication for AED to assess effect modification by the underlying reason for AED prescription.
Significant proteinuria was managed by dose interruption and/or modification with no indication for renal support.
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