The elements to be taken into consideration in the indication, design and realization of the bypass surgery in the treatment of the MCA aneurysms are discused.
We collected the following information: name of the active substance, year of approval, indication, design of the pivotal trials, number of patients in each trial, primary and secondary end points supporting the approval and difference in survival between arms, when available.
The evolution of the procedure, indications, design issues, surgical technique, results, complications, and longevity is discussed.
Unicompartmental replacement of the knee for isolated medial or lateral arthrosis has been a controversial procedure regarding indications, design, efficacy, and longevity since its inception in the late 1950s.
However, routine practices are very different among centers and countries, regarding CMA indications, design and resolution of microarrays, notification and interpretation of Copy Number Alterations (CNA).
Phase III trials with erlotinib in non-small cell lung cancer and pancreatic cancer are in progress, as are a range of studies in various indications designed to optimize the use of erlotinib alone and in combination with chemotherapy, radiotherapy, and other targeted agents.
Moreover, the presented analysis provides some useful indication to design handset antenna considering hand effects.
Defecation frequency provides an indication for design parameters relating to treatability as it provides an indication of how often a facility may be used.
We agree with Migaud et al. [ 20] that M-o-M bearing couplings are still useful provided that surgical indication, implant design, and surgical technique are suitable.
Indication, study design, patient age, length of follow-up, and type of procedure had no statistically significant influence on the magnitude of the ceiling effect (p-values all > 0.05).
This is one of the downsides of the European PDO and PGI (protected designation of origin and protected geographic indication) schemes, designed to protect the special, distinctive status of regional foodstuffs.
