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Industry sponsors may be hesitant to submit an already approved drug for a new indication because of what may be perceived as unnecessary expense and the considerable risk of not meeting primary endpoints with randomized controlled trials.
An instrumental drift is the continuous or incremental change over time of the indication because of change in metrological properties.
Only 6 of our patients had an arthroscopic evaluation, for whom there was an indication because of new trauma or delayed ACL reconstruction.
The off-label use of misoprostol, a prostaglandin E1 analogue, has entered into clinical practice for this indication because of its strong uterotonic properties, and its ease in oral administration, stability at ambient temperatures, wide availability, and low cost.
In addition to the lack of socioeconomic data in registHER, an inherent limitation of this study is possible "confounding by indication" because of the nonrandomized, observational nature of the registHER study.
Radiesse® (calcium hydroxylapatite [CaHA]; Merz North America, Inc., Raleigh, NC, USA) is an ideal agent for this indication because of its ability to provide both replacement volume and collagen biostimulation as a primary mechanism of action.
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It is important that patients with a CrCl <15 min/mL should not receive rivaroxaban for any of the approved indications because of the risk of drug accumulation.
Radiesse® (calcium hydroxylapatite) is an effective dermal filler for a number of indications because of its volumizing effect and the ability to stimulate neocollagenesis.
It was not possible to investigate the consistency of associations with glucocorticoid therapy in different disease indications because of the small number of patients available who were not being treated for obstructive pulmonary disease.
Von Schulthess et al. [ 27] suggest that the cost-effectiveness of integrated PET/CT is superior to that of PET alone in some indications, because of both the higher diagnostic accuracy of integrated PET/CT and the potential for higher patient throughput.
Some in the industry see the loan as an indication that because of their heavy indebtedness, they are no longer able to borrow substantially from traditional commercial lending institutions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com