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Exact(8)
Any diagnostic test has an indication area of prior probabilities wherein the gain in diagnostic certainty outweighs its loss.
Here, we investigate whether indication area and the maximum diagnostic gain are robust measures if we assume test dependence, alternative physician's heuristics, and varying patient's utilities.
We propose net diagnostic gain and indication area as more appropriate measures of test performance; then, the loss in certainty due to misclassification and the information of "no test" would be performed are taken into account.
"One element that is unique is our strategy for discovering new drugs, which involves pursuing novel mechanisms of action irrespective of the targeted potential indication area," said Magnetti.
Appropriate as defined in the legal framework of Social Code Book V means as compared with other treatment strategies within the same indication area.
The connections of pharmacological agents with disease areas outside their main indication area appear to be related to the expression and activity of their drug targets within these organ systems.
Similar(52)
Large-scale genetic screens in zebrafish carried out since the early 1990s have led to the identification of therapeutically relevant genes in several indication areas, including cardiovascular, neurological, gastrointestinal, musculoskeletal, and metabolic disorders [5], [6], [7], [8].
The experts were also requested to suggest additional substances and indication areas for assessment and possible inclusion in the FORTA List.
Current perspectives on p38αMAPK inhibitor drugs are influenced by perceived failures in some disease indication areas even while others continue to show promising outcomes.
Although most of these have been tested for toxicity towards cancer cells, they could potentially be applied in other indication areas such as autoimmune and chronic inflammatory disorders.
The purpose of this study was to identify textual features that enhance the effectiveness of biomarker information retrieval for different indication areas and diverse end user perspectives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com