Although dose-dependent uptake in tissues was observed, a constant tissue-to-blood AUC ratio was reached at 450 mg for all tissues, indicating target antigen saturation.
For the spleen, liver, bone marrow, kidney and lung, dose-dependent uptake of 89Zr-RG7356 was observed, indicating target antigen-mediated specific uptake in these tissues.
Opioid antinociception might be initiated by activation of OR outside the CNS, indicating targeting of peripheral OR could be useful in the treatment of chronic pain.
These cases can be regarded as concept proofs indicating targeted engineering might help to create high-efficiency cell factories based upon constructed biological components.
Additionally, under these conditions the expression of several genes in branched chain amino acid pathway was severely suppressed indicating targeted gene inactivation.
Elevations in 2′-dU were observed indicating target inhibition.
Interestingly, panobinostat activity was only seen in KIT-positive GIST models indicating target specificity.
Likewise, CanSINE integration sites within Feliformia share similar AT-rich motifs (Tables S3 and S4) indicating target site preferences [ 53].
The clinical data, so far, using F19 (murine anti-FAP mAB) or sibrotuzumab (humanized F19) showed antibody accumulation in the tumor tissue indicating target specificity [ 22].
YFP patterns were similar to those observed in protoplasts transiently expressing PGL34-YFP (Fig. 3B), indicating targeting of the YFP cargo to plastoglobules in planta.
