Sentence examples for indicating pathway from inspiring English sources
Others have also demonstrated that mesocortical projecting dopamine neurons undergo synaptic plasticity following a painful experience (Lammel et al., 2011), indicating pathway specific activation of dopamine neurons.
Of the 10 KEGG canonical signal transduction pathways investigated, Wnt was the most commonly overexpressed pathway in the TNBC subtypes indicating pathway perturbation in these types of breast cancers (Additional file 3: Figure S4).
Similarly, in a mouse model of CNS PNET, induced by WNT/ β-catenin pathway activation in conjunction with Myc expression and p53 knockout, tumours displayed regions of differentiation, but not in cells displaying nuclear β-catenin, indicating pathway activation inversely correlated with differentiation (Momota et al, 2008).
Strikingly, there was a large overlap in the drugs identified that attenuate infection in both cell types, indicating pathways utilized by the virus in both mammals and insects (p<10−16; Figure 2E).
In Figure 3 of the original manuscript published online, the arrows indicating pathways were incorrect.
Black solid arrows indicate pathways with evidence from rice, grey solid arrows indicate pathway with evidence from Arabidopsis, and broken arrows indicate pathways without direct evidence.
Positive and negative PAS values indicate pathway up- and down-regulation, respectively.
The authors present PSFC, a cytoscape app for the analysis of pathway signal flow to indicate pathway activity states.
The "% Shared annotations" represent the percent of shared relative to the total annotations for the indicated pathway.
As an output this algorithm produces Pathway Activation Strength (PAS) values, where positive and negative PAS values indicate pathway up- and down-regulation, respectively.
A p-value is calculated for each pathway using Fisher's exact test [ 22] to indicate the significance of the pathways, using a 2 × 2 contingency table where the rows indicate pathway membership and the columns indicate cluster membership [ 23].
