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Twenty-four of the 39 animals (61.5%) with hepatic and/or pulmonary metastases were positive for CK-20 RT-PCR indicating dissemination of tumor cells in the bone marrow.
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Treatment with fluconazole caused Williamson's lesion to shrink and eventually all but vanish, and no new lesions have appeared, nor has he had the lumbar back pain and the headaches that would indicate dissemination to the spine and the brain.
This presence in the systemic tissues indicates dissemination was occurring.
However, isolation from the liver, indicating systemic dissemination of C. albicans, was only sporadically successful.
Spread to mLN was not significantly affected in any of the groups, indicating that dissemination to deeper sites of the GALT was not affected in the Il17ra−/− mice at this early stage of the infection (p≥0.05; Fig. 2B).
In contrast, there were significant differences in the length of survival between the WT and all their isogenic T3SS mutant strains (Figure 6) indicating that dissemination of P. aeruginosa in the setting of neutropenia is modified by the T3SS.
18 These findings should not be interpreted as indicating that dissemination of information on the importance of infant sleeping position was either ineffective or harmful.
In the spleen, liver and lung, EBER-positive cells were sporadically observed in focal lesions, indicating hematogenous dissemination of tumor cells.
Similarly, clusters in the ventricle wall were found after hindbrain ventricle infection and displayed clear growth into the parenchyma, indicating that dissemination of bacteria can occur throughout the entire brain after local inoculation of bacteria into the parenchyma and the hindbrain ventricle.
The presence of disseminated tumor cells in the bone marrow (DTC-BM) seems to indicate hematogenous dissemination and proved to be prognostically significant for the subsequent development of metastases and tumor associated death in many studies [ 3- 6].
Quantitatively, the increase from 18% to 38% might indicate wider dissemination of these technologies, or might be due to sampling variation.
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