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Lysates from tissues incubated in 6-carboxyfluorescein fluoresced proportionately to concentrations of IAM, indicating disruption of cellular membranes.
Moreover, preplacode cells fail to express pax8 and pax2.1, indicating disruption of early stages of otic induction in fgf3-depleted ace/ace mutants.
The carbonyl stretching vibration of the ibuprofen dimer shifted to higher wavenumber in the infrared spectra of 2 1 drug carrier mole ratio solid dispersions, indicating disruption of the ibuprofen dimer concomitant with hydrogen bond formation between the drug and carrier.
The extent of ELM and EZ disruptions and RPE atrophy was graded based on a grading scheme of 0 to 3, with grade 0 defined as no disruption/atrophy, grade 1 defined as loss of 1% to 33% of the band, grade 2 defined as 34%to66%6% loss, and grade 3 indicating disruption or loss of these bands in more than 66% of the length of the horizontal sub-foveal SD-OCT scan.
Line profiles of transfected cells confirmed the correlation of the EGFP-Vt wild type with actin filaments and paxillin signals, while no such correlation was evident for the EGFP-Vt-ΔEx20 signal, indicating disruption of targeting (Fig. 7E, E').
After ∼9 12 hours of exposure to Wild Type Aβ (1 40), the bilayer developed large regions of increased bilayer roughness, indicating disruption of the bilayer's structural integrity induced by the presence of Wild Type Aβ (1 40) (Fig. 4B D).
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Decrease in intensity of visible peak at λ max indicates disruption of the chromophoric group, i.e., azo group.
Decreased cadherin-1, increased α-smooth muscle actin and fibroblast specific protein 1 in kidney tissue indicated disruption of normal tubular architecture.
Differences in levels of phosphorylated CagA could indicate disruption of the T4SS responsible for its translocation.
These results indicate disruption of the mitochondrial membrane potential by down-regulation of NEFH.
The observed malformations, including hypospadias, indicate disruption of androgen action.
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