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We also observed strong and sometime specific responses to epitope variants after the sequences of the founder epitopes became undetectable (variants TR8 and TT8 of Pol TI8, and N5D7DW9 of Env NW9; Figure 8A and B) or minor in the sampled viral population (variant Q3LW11 of Gag QW11; Figure 8C), indicating development of de novo responses against the variants.
At baseline, a 61 to 63% decline in ejection fraction as compared to the non-infarcted sham group was evident in all LAD-ligated groups (EF %: control 34.56±1.67; L6-WT 32.91±2.38; L6-HGF 34.80±2.19) indicating development of significant heart failure.
The chest X-ray revealed air lining the cardiac border, indicating development of pneumomediastinum.
Measurements of their blood glucose and ketone revealed elevated values (Glucose: ∼20 mmol/L and Ketone: ∼6 mmol/L), indicating development of ketoacidosis.
The Ki67 index from pre-castration mice was similar to the control mice treated with water, indicating development of castration resistant growth.
However, images illustrated in their publication reveal architectural abnormalities and cytologic atypia, both of which are indicating development of ectopic crypts and adenomas rather than simple lengthening of the crypts, which would indicate hyperplasia only.
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The associations indicate development of advanced argillic, sericite, and potassic alteration zones under the crater.
Computational simulations have indicated development of continuously recirculating flow pathways in/out of the fiber bundle with impeller mixing [25].
We chose the Oxford, WOMAC, and KOOS, as these methods indicate development of OA and have proven their reliability in assessing and evaluating such patients.
Process intensification measured and analysed in terms of space intensification, application flexibility, capacity flexibility, energy saving and cost advantage parameters indicate development of an economically viable green process.
Sequence analyses of genes from seven infectious L. interrogans serovars indicated development of sequence diversity through recombination and intragenic duplication.
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