A number of observations indicate an instructive character of microRNA regulation in carcinogenesis.
Restoring CTCF reinstates proper architecture on altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding.
These results indicate the necessity of an instructive biomaterial-based scaffold to direct stem cell differentiation, proliferation, paracrine activity as well as regulation of ECM deposition.
Together, our results indicate that Myc has an instructive role in damaged-induced ISC proliferation in regenerating Drosophila midguts as well as a permissive role in ISC proliferation during normal tissue homeostasis.
However, Wnt5a has been found to be required for stereocilia orientation in the cochlea, indicating that Wnt5a can play an instructive role in PCP during development [4].
Our results indicate that instructive signals in the climbing fibers are not necessary for cerebellum-dependent learning.
In addition, we demonstrate that the collective motion of lowly and moderately variable genes within the genome vehicle, which are often considered as noisy and insignificant, play an important role in the formation of the neutrophil attractor, perhaps indicating the non-instructive signaling of genes related to small-amplitude DNA motions [24] [25].
The timing of expression, and the impact of knockdown on excitatory synapse formation, indicates that miR-132 coordinates an instructive transcriptional program that is necessary for the integration of newborn neurons into the adult central nervous system.
Finally, it seems instructive to note that while individual risk perception does not always result in actual behaviour change, it may still indicate a readiness to change [ 31].
Our data indicate that Notch signalling, activated by JAG2, maintains pMN progenitors in an undifferentiated state but also provides an instructive signal that blocks the fate switch from MN to OLP.
