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The daily rhythm of core body temperature was entrained by treatment, with the phase shifted and the amplitude decreased by night feeding indicating alteration of the central clock.
Moreover, fibrotic septa composed of collagens and α-smooth muscle actin-positive cells were found between the central and portal veins, indicating alteration of the parenchymal architecture.
Among the 588 miRNAs checked, 49 miRNAs were downregulated while 27 were upregulated, indicating alteration of miRNA levels caused by ionizing radiation.
Moreover, neurofilament 200 and dystrophin, which are involved in organization of cell projection and cytoskeleton, decreased, indicating alteration of cytoskeleton in CBKOTg.
To our knowledge, the present study is the first to suggest that hyperuricemia may impair vasorelaxation via BKCa, indicating alteration in smooth muscle hyperpolarization.
In addition to careful mapping of vascular lesions and histological signs of non-neurodegenerative disorders, immunostaining for p62/ubiquitin (that is, markers indicating alteration in the ubiquitin proteasome system) may be used to screen for neurodegenerative pathology.
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The ratio of NCAM/synaptic proteins is also changed in some cases, indicating alterations in mature/immature synapses.
However, 2-month-old TGR rats showed a considerable reduction in amplitudes of both scotopic and photopic ERG responses, indicating alterations of both rod and cone system.
Likewise, modification of IR spectra indicating alterations in structure of uHSA agrees well with published data about the physicochemical peculiarities of albumin in chronic uremia.
The differentiation of epidermis generated in the presence of old Fp (Fig. 8C) and Fr (Fig. 8D) was equivalently poor, indicating alterations of Fp with age.
At pH 9 and pH 6 we observed the repression of several genes indicating alterations of the carbon metabolism.
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