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In fact, for all three crosses the female: hermaphrodite ratios fit a 2 1 (all P > 0.80), potentially indicating a lethal genotype.
RICESLEEPER2 mutants produced a normal amount of seeds, but RICESLEEPER1 mutant plants produced mostly empty panicles, yielding only very few seeds, indicating a lethal embryo defect.
As a method to reduce the computation time of the GA optimization, the GA was forced to always include (through fixed inclusion of a "1" in the individual genotype) reactions that were determined to either 1) reduce maximal product yield to zero, or 2) reduce maximal biomass yield to zero (indicating a lethal knockout).
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Two model specific assumptions had to be considered: first, we have to assume that secreted molecules do not influence the regulatory system, and second, that metabolites with increasing concentrations indicate a lethal state.
Approximately 35% of Europeans and 52% of Chinese people are known to carry at least one of these variants, but no individual was noted to have all three variants, indicating an embryonic lethal combination.
Genotype analysis of 14 litters of newborn mice (n = 121) and 12 litters of E8.5 18.5 embryos (n = 92) from Matr3Gt-ex13 heterozygous crosses revealed no homozygotes, indicating a prenatal homozygous lethal phenotype (Table 1).
Importantly, the PCR products from the two different cell lines were labeled with two different fluorescent dyes (Cy5 and Cy3) before hybridization to facilitate the identification of products that were selectively depleted in the KRAS mutated cell line, indicating a potential synthetic lethal interaction.
The data reported in Table 8 strongly indicate a quantitative lethal effect of the Y heterochromatin.
A chart shows that special operations actions in the Horn of Africa resulted in captures just 25percentt of the time, indicating a heavy tilt toward lethal strikes.
Although the exact role of PI31 in cells is still a matter of debate (Li et al. 2014), recent studies indicate that it can activate the 26S proteasome in vitro and positively control proteasome activity in living cells; in Drosophila, loss of PI31 function is lethal, indicating a basic cell function.
Antibody mediated neutralization of IFN-γ provided significant protection against lethal TSS indicating a critical role for IFN-γ in the lethality of TSS.
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