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The proliferation indices for these lesions showed modest increases over normal epithelium, and positive p53 staining was evident in 4 of 10 cases, indicating a disruption of the keratinocyte cell cycle in these lesions.
Although IFNγ levels per se were not affected, IFNγ target genes were significantly down-regulated in rAd.A20, as opposed to rAd.βgal treated livers, indicating a disruption in IFNγ signaling.
In addition, immunostaining of Hes1 on back skin sections revealed a loss of staining in Rbpj/Tgfb3-Cre hair follicles at P8, indicating a disruption of Notch signaling in the follicular lineages (Figure 3E).
For example, in the case of Ste4p, the protein is uniformly distributed on the cell membrane in these strains (Figure 4A) indicating a disruption of the polarizing positive feedback mechanisms.
In ush1c morphants, both proteins were present in the OPL, but they were remarkably misaligned and less colocalized, indicating a disruption in synaptic organization (Fig. 7B).
Furthermore, As exposure in early pregnancy was associated with reduced T-cell numbers in the placenta, indicating a disruption of immune balance.
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An activity decrease here during overwhelming flashback experiences could indicate a disruption to normal executive processes, or might reflect disrupted patterns of input and output to and from other flashback-affected areas.
Pigment fragmentation indicates a disruption in coral tissue that likely impedes translocation of energy within a colony.
These findings indicate a disruption in inhibitory and switching processing efficiency in the high anxiety group, and are in agreement with top-down processing biases of attention theory.
Newly published data indicate a disruption in the sarcoplasmic reticulum (SR) following a single bout of SIT [29].
Furthermore, sudden strong activity attenuation has always indicated a disruption, even before any alterations in chemical parameters were affected.
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CEO of Professional Science Editing for Scientists @ prosciediting.com