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The transient inhibition of PI3K and the absence of toxic effects observed in JIMT-1 and KPL-4 cells during LY294002 treatment, a specific inhibitor of PI3K, indicates the specificity of P-1257 inhibitinging an important survival pathway in these cells.
The high positive rate of GPC3 in hepatocellular carcinoma indicates the specificity of GPC3 in hepatocyte-origin carcinogenesis.
This indicates the specificity of the identified oxidized mRNA species.
This result clearly indicates the specificity of gene knockdown by antisense expression.
Finally, the absence of murine transcripts (Desmin and MyoD) in CHQ cultures alone indicates the specificity of the primers to amplify only murine transcripts (Figure 2C).
Absence of such effects using overexpressed Ste2p, or the human Edg2 receptor, that is known to couple to Gpa1p in yeast [18], indicates the specificity of the Frizzled-mediated growth inhibition (Fig. 3A).
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No amplification band was observed by using the non-specific rabbit IgG, indicating the specificity of the DNA immunoprecipitation and ChIP assays.
Control groups kept a basal level of Bm86-specific reactivity equal to that of preimmune sera, indicating the specificity of the assays.
The CXCR4 antibody 12G5 inhibited SDF-1 binding to HBMEC indicating the specificity of gp140 binding to HBMEC.
Therapeutic index values were determined by the ratio of MHC/MIC, indicating the specificity of peptides against bacterial and eukaryotic cells, respectively.
These data indicated the specificity of the raised antibodies to the LND residues in the immobilized LND-BSA, but not BSA molecules.
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