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This finding clearly indicates that differentiated cells must contain a tumorigeneic cell population that is different from the ES cells.
In the context of induced pluripotency, this indicates that differentiated cells are robustly resistant to reprogramming to a more primitive state.
Bioinformatic analysis of microarray data indicates that differentiated trisomic APCs exhibit global expression profiles with similarities to the malignant astrocytoma cell line.
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Expression of PL-I protein, a specific marker for TGCs, was detected after day 6 of differentiation using western blotting (Fig. 1a), indicating that differentiated TSCs (dTSCs) could be regarded as TGCs as early as day 6 of differentiation in terms of hormone expression.
Immunofluorostaining indicated that differentiated human MAPCs (hMAPCs) expressed collagen II.
Two days after ischemia-reperfusion injury (IRI), 50.5% of outer medullary epithelial cells coexpress Ki67 and RFP, indicating that differentiated epithelial cells that survived injury undergo proliferative expansion.
Those results indicate that differentiated service with priority queueing has a bigger impact in OSA networks than in conventional networks and should thus be actively used when they carry multiple classes of traffic with different QoS requirements.
These results indicate that differentiated cells are more susceptible to MCMV because the MCMV genome can enter the nucleus more efficiently than in ES cells.
Moreover, these results further indicate that differentiated tumour cells were derived from the Sca1-driven, MafB-expressing stem cells.
This analysis also indicated that differentiated fibroblasts (FIBs) are much closer to MSCs than to HSCs, but they are also well separated from the mesenchymal lineage.
Further, as the fibroblasts were included in this part of the analysis, the results indicate that differentiated cells can also have similar effects.
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