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The presence of active TrPs indicates sensitization of muscle nociceptors in both TMD and FMS since high levels of neuroactive mediators [12, 13] and lower pressure pain thresholds [34 37] have been found in active TrPs.
The presence of pressure pain hypersensitivity in distant pain-free areas indicates sensitization of the central nervous system in pianists suffering from neck pain; however, the absence of pressure hyper-sensitivity over the symptomatic areas makes this assumption inconclusive.
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The presence of active TrPs indicate sensitization of peripheral muscular nociceptors since high levels of chemical mediators [33, 34] and greater mechanical hypersensitivity [35, 36] have been found in active TrPs.
Five factors correlated with graft rejection: (1) previous blood transfusion; (2) a positive relative response in mixed leucocyte culture indicating sensitization of patient against donor; (3) a low number of marrow cells used for transplantation; (4) marrow grafts from male donors; and (5) lack of infusion of viable donor buffy coat cells in addition to the marrow for transfused patients.
In 13 of these, significant enhancement of radiation effect occurred under ambient conditions, indicating sensitization of naturally hypoxic cells.
Tender points and widespread pain may indicate sensitization of the nociceptive system, but notably, they played different roles in relation to back pain and leg pain in the present study.
These results indicate sensitization to the effects of TMZ leading to a major increase in TMZ-induced cell death in T98G cells as a result of treatment with scL-p53 nanocomplex.
As per standard we accepted FSIgE levels of ≥0.35 kIU/L to indicate sensitization.
Positive values indicated sensitization.
Convergent research indicates that sensitization of the central nervous system pathways related to pain is a key mechanism in fibromyalgia (FM) [ 221].
A positive IgE test may indicate allergic sensitization of clinical importance (Berg and Johansson 1974; Wide 1973), but may also be present in asymptomatic individuals (Bousquet et al. 2006).
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